Benefits Of CBD Oil For Pain: 12 mind-blowing facts!

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The continuous use of pain killers can have substantial effects on your health. But it is not the only way you can deal with your pain. There are several alternative strategies that can be used for the management of pain. The use of CBD Oil For Pain is one such way that is scientifically proven to help with difficult to treat pain disorders.

But how CBD oil helps the pain? What is the mechanism and benefits of using CBD oil over conventional methods for pain relief? This article will walk you through these and a number of similar questions.

Let’s get to it!

7 Ways CBD Oil Helps Ease Pain

Following are the main ways through which CBD oil helps ease the pain.

# 1: CBD Oil Relieves Pain by Acting on the Cannabinoid Receptors

The endocannabinoid receptors are extensively represented on the central nervous system (brain and spinal cord) and peripheral nervous system.

The main receptors types in this system include the CB1 and CB2 receptors.

Research has shown that CB1 receptors are present in abundance in the parts of the brain that are associated with the control of pain.

Research has proven that blocking the CB1 receptors in the periaqueductal area of the brain leads to pain exacerbation. [3]

In simple words, the cannabinoid receptors in the brain help blunt the pain.

In addition, these receptors are present on the nerves as well. The peripheral nerves contain both CB1 and CB2 receptors.

CBD oil helps in the activation of these receptors. As a result, it helps soothe the nerves and manage chronic pain disorders. [3]

# 2: CBD Oil Reduces Muscle Spasms

Pain exacerbates muscle spasms, and muscle spasms can worsen your pain. Another way CBD oil can help ease the pain is by relaxing your body muscles.

It has been consistently shown through research that the use of CBD oil helps improve muscle function and reduce muscle spasticity.

Several clinical studies have shown that the use of CBD oil in individuals with Multiple Sclerosis helps reduce spasticity and related pain. [4]

# 3: CBD oil Reduces Inflammation

As mentioned, pain is your body’s way of warning you that something is not just right. Generally, pain and inflammation go hand-in-hand.

Whenever any part of your body gets damaged, infected or injured, the body starts the mending process.

One way your body does this is by recruiting the immune modulating cells to the damaged site. These cells include neutrophils and lymphocytes.

Once these immune cells are at the damage site, they release a number of chemicals including interleukins, interferons, Tumor Necrotic Factor (TNF), cytokines, and so on.

These mediators have several effects on your body. One effect these mediators have on your body is increasing inflammation, triggering pain response, and making your nerves more sensitive.

CBD oil can help manage pain through its effect on body inflammation. CBD oil can help achieve a tremendous reduction in body inflammation and pain.

One way CBD oil achieves this is by reducing the inflammatory chemicals like interleukins and TNT. Moreover, it helps inhibit enzymes like Cyclooxygenase 2 (COX-2), which is responsible for producing a number of inflammatory chemicals. [5]

# 4: CBD Oil Can Control Pain Through Immune Modulation

Again, pain is just a symptom and one of the ways your body tells you that there is something wrong.

Pain is a part of a broader scheme of events that involves immune activation, inflammation, the release of several chemicals, nerve activation, and eventually the sensation of the pain.

The immune system plays a key role in triggering a painful response.

As mentioned before, whenever a part of your body gets injured, damaged or infected, the immune system of the body springs into action.

Subsequently, several types of immune cells like lymphocytes and neutrophils migrate to the site of damage.

When they reach the site of damage, they release chemicals to send out a signal to the brain and to the body in general to activate protective responses.

Pain, therefore, can be the result of your immune system reacting to a stressful event.

ain, therefore, can be the result of your immune system reacting to a stressful event.

At times, there can be an immune dysfunction that can lead to an exaggerated immune response.

As a result, it can lead to increased activation of the immune system, a greater release of the inflammatory chemicals, and heightened pain.

CBD oil can regulate the amount of immune response your body generates by controlling the growth and activity of the immune cells.

Research suggests that in cases of immune dysregulation, the use of CBD oil can lead to a reduction in the number of immune-mediating cells, which can then lead to a reduction in the inflammatory response and pain. [5]

# 5: CBD Oil Helps Reduce Oxidative Stress

 Oxidative stress is a part of the broader scheme of events that set into motion once you experience any injury, infection or damage.

Oxidative stress means there is an increased amount of highly reactive oxygen molecules called the Reactive Oxygen Species (ROS).

These oxygen molecules are extremely unstable and reactive and can damage anything they come into contact with.

The main function of these ROS is to destroy anything (like bacteria or viruses) that might be damaging your body.

In certain instances, your body can keep producing a high amount of these reactive molecules.

These reactive molecules can then damage your normal body tissues and can damage your body nerves as well. This can worsen your pain.

CBD oil can help with this aspect of pain as well. CBD oil helps put a stop to the series of chemical reactions that result in the production of ROS.

The potent antioxidant components in CBD oil can, therefore, help reduce the oxidative stress and the amount of pain as well. [6]

# 6: CBD Oil Improves the Mood

Pain is not just a physical symptom. It can have a drastic effect on your emotional and psychological wellbeing as well.

In return, the state of your mind can have a profound effect on your pain response.

Research has consistently shown that individuals struggling with pain disorders are profoundly more anxious or depressed.

It can work the other way around as well. In other words, anxiety and depression can make you more sensitive to pain and exacerbate any existing pain reaction you might be having.

CBD oil can help you on this front as well. Research has shown that the use of CBD oil can help improve psychological wellbeing by improving depression and anxiety.

This, in turn, can help improve pain as well. [3]

# 7: CBD Oil Improves Sleep Quality

Another thing pain sufferers struggle with- which then exacerbates their pain- is the quality of their sleep.

Not getting enough sleep can make you feel fatigued, tired, and can potentiate your pain.

CBD oil can help you relax and can help you achieve a peaceful and good quality sleep. This can help ease your pain.

All of that is without the psychoactive effects as CBD oil is low in THC and only contain cannabinoids.

Types of Pains CBD Oil Helps With

Most of the pain killers have a major downside. In addition to having a variety of side effects, they have a narrow spectrum of effects.

In other words, one pain killer is useful for only one type of pain disorder.

CBD oil, in contrast, is versatile. Research has shown it to be effective for the management of a variety of pain disorders.

Following are some of the pain disorders in which the use of CBD oil has proven to be effective.


Migraine is a debilitating type of headache that affects a significant number of population.

Migraines can cause headache, visual and auditory aura, nausea, vomiting, and can cause a significant sick leave from work.

Migraine pathophysiology is complicated, but here we will try to summarize it in a simplified way.

Trigeminal ganglion is a part of your nervous system that plays a crucial role in the pathophysiology of migraine.

When you are about to experience a migraine attack, the neurons associated with this ganglia release a chemical called the calcitonin gene-related peptide (CGRP).

CGRP has multiple effects on the nervous system. It acts on a type of cells called the Mast Cells (MCs). Mast cells increase the release of several inflammatory chemicals like cytokines.

Moreover, it also acts on the local blood vessels and increases the supply of blood to different parts of the brain.

The cumulative effect of these processes is that it makes you experience headache and other sensory features associated with a migraine attack. [7]

The endocannabinoid system and CBD oil can help with migraine attacks in several ways.

Research suggests that the active constituents in CBD oil can prevent the release of CGRP from the trigeminal neuron nerve endings.

It is can also prevent the release of inflammatory chemicals from the mast cells that can prevent the dilatation of blood vessels in the brain.

Finally, it calms your nerves and brain activity and can prevent headache and other sensory symptoms associated with a migraine attack. [7]


Fibromyalgia is difficult to diagnose and even more difficult to manage.

Fibromyalgia is a condition associated with extreme sensitivity to pain. It is associated with a phenomenon called hyperalgesia.

Hyperalgesia is a condition where slight pressure and pain over a certain body part would cause excruciating pain.

The use of CBD oil for the management of fibromyalgia has got multiple effects.

While we are still trying to find out how CBD oil might help with fibromyalgia but we might have some clues.

Researchers have found that individuals with fibromyalgia have lower levels of endocannabinoids in their bodies.

The lower levels of these cannabinoids might be the reason that the body becomes sensitive to pain and gives an exaggerated response even to the slightest pain.

Researchers have also found that the use of CBD oil might help restore the balance of endocannabinoids in the body.

This can help reduce the amount of pain and can help reduce hyperalgesia (sensitivity to pain).

Moreover, it can also help improve other symptoms of fibromyalgia. It can help improve the overall quality of life, sleep quality, and mood. [8]

Arthritis and Osteoarthritis Pain

Pain is a consistent feature of different types of arthritis like rheumatoid arthritis and osteoarthritis.

The pain associated with these conditions is the result of a number of variables.

The most important component adding considerably to the pain in these conditions is the damage done to the joints by the inflammation and the oxidative stress.

Another element making these conditions painful is the nerve damage found in these conditions. [9]

CBD oil can help improve the pain and overall disease progression in a number of ways. Due to its extremely potent anti-inflammatory properties, CBD oil is able to help reduce the level of inflammation.

This reduces disease progression as well as reduces the amount of pain associated with these conditions. [9]

Also, CBD oil is able to reduce the amount of oxidative stress. Oxidative stress damages the joints, surrounding tissues, and nerves and can exacerbate the pain.

The antioxidant properties of CBD oil can help reduce the joint and nerve damage and can help minimize the pain. [9]

Finally, due to several reasons, your nerves experience substantial damage in conditions like rheumatoid arthritis and osteoarthritis.

In simple words, your nerves go haywire and get exposed to friction and stress. This results in excruciating pain.

CBD oil can help save the nerves as well. It helps protect the nerves from oxidative and inflammation damage.

Also, it can help these nerves regenerate and withstand the stressors. [9] More details on this are in the next section.

Cancer-Related Pain

Pain is one of the major complications associated with a variety of cancers. Pain can mean active disease, disease progression or spread.

Cancer-related pain is often severe and difficult to control.

The pain in different cancers often requires continuous administration of morphine that comes with its own plethora of complications.

The use of CBD oil and other cannabinoid containing products is an effective alternative.

It is a good adjuvant that can reduce the reliance on conventional opioid pain killers.

Several detailed reviews have demonstrated the effectiveness of CBD oil and other similar compounds in reducing the severity of cancer-related pain.

These reviews have shown that CBD oil is associated with a better safety profile and can significantly reduce opioid dependence. [10]

Neuropathic and MS-Related Pain

Neuropathic pain is a type that is different from the pain disorders caused by other types.

This type of pain is exclusively due to nerve damage. The nerves in such conditions undergo extensive damage and become extremely painful.

The drugs commonly used for the treatment of neuropathic pain include medicines like gabapentin.

These medicines work by calming the nerves and by reducing the activity of nerves. Like all other drugs, these medicines do come up with a significant number of side effects.

Another disorder associated with severe neuropathic pain is Multiple Sclerosis (MS).

The neuropathic pain in MS is due to excessive release of glutamate. Excessive glutamate release in the brain leads to excessive brain activation and pain sensitization.

The use of CBD oil and similar products can help deal with the neuropathic pain in a number of ways.

CBD oil, due to its antioxidant and anti-inflammatory properties, can help protect the nerve structure. [11]

Moreover, CBD oil is able to reduce the activity of the glutamate system in the brain. This reduces the unnecessary firing of neurons in the brain and reduces sensitivity to the pain.

Finally, CBD oil is able to reduce neuropathic pain by calming the nerves. This is due to the ability of CBD oil to increase the release of different chemicals.

The most important group of chemicals in this regard is the beta-endorphins. [11]

Ways to Use CBD Oil for Pain

There are multiple ways you can use CBD oil for the management of pain. Some of these are mentioned below.

Methods of Oral Ingestion

Here are some methods for oral ingestion to use CBD oil for pain relief.

  • Tinctures

Tincture method involves just putting a couple of drops on your tongue and swallowing them. However, things can get a bit messy sometimes.

To use CBD oil in tincture form, simply take a CBD oil bottle and put two or three drops on your tongue and swallow them.

  • Edibles

You can also add CBD oil in different food products. When you swallow the oil, it passes through your digestive system and then enters directly into your bloodstream. This way you get the direct benefits.

To add it in food products, simply sprinkle three or four drops of CBD oil in your food. In fact, you can spray it on any food of your choice.

  • CBD vaporizing

CBD oil can be inhaled using a tool, known as a vape, which is a concentrated version cannabinoid. This inhaled CBD passes directly through the lungs and gives immediate effects. However, you have to continue to take the doses regularly for long-term effects.

Some other oral ingestion methods include using sprays and concentrates.

Topical Application

The great thing about applying CBD oil on the skin is that the human body absorbs 90% of anything it comes in contact with, so this method is quite fast acting and effective. However, the major drawback is that it has short lasting effects as compared to oral ingestion.

  • Applying manually

Here is the method to use CBD oil for topical use. Just take CBD has oil and heat it on the stove until bubbles form. After that, remove the heat, let the mixture cool, and apply it on the skin.

  • Applying through Skin Patches

You can also use CBD oil in the form of skin patches, which are small adhesives, which are applied to the skin. They are usually effective for an extended period.

CBD Oil For Pain - Pinterest


To conclude, CBD Oil For Pain is an effective, potent, and scientifically proven method to detail with pain disorders. It helps deal with acute pain.

Moreover, the use of CBD oil is an effective strategy to prevent pain in the long run as well.

Above all, CBD oil is a natural remedy and does not come with the horrible side effects that you would experience with the ordinary pain killer.

However, it is still important that you stay in touch with your healthcare provider.

Always involve them in the decision making and make sure whatever condition you have is being looked at by a qualified professional.


  3. Ethan B Russo. Cannabinoids in the management of difficult to treat pain. Ther Clin Risk Manag. 2008 Feb; 4(1): 245–259.
  4. Thorsten Rudroff, et al. Cannabidiol to Improve Mobility in People with Multiple Sclerosis. Front Neurol. 2018; 9: 183.
  5. Prakash Nagarkatti, et al. Cannabinoids as novel anti-inflammatory drugs. Future Med Chem. 2009 Oct; 1(7): 1333–1349.
  6. Natalya M. Kogan, et al. Cannabinoids in health and disease. Dialogues Clin Neurosci. 2007 Dec; 9(4): 413–430.
  7. Pinja Leimuranta, et al. Emerging Role of (Endo)Cannabinoids in Migraine. Front Pharmacol. 2018; 9: 420.
  8. Ethan B. Russo. Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes.
  9. Holly T. Philpott, et al. Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. Pain. 2017 Dec; 158(12): 2442–2451.
  10. Blake A, et al. A selective review of medical cannabis in cancer pain management. Ann Palliat Med. 2017 Dec;6(Suppl 2): S215-S222
  11. Ethan B Russo. Cannabinoids in the management of difficult to treat pain. Ther Clin Risk Manag. 2008 Feb; 4(1): 245–259.

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